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IGFBP3 Antikörper (AA 101-210)

IGFBP3 Reaktivität: Human WB, IF Wirt: Maus Monoclonal 4-IGFBP unconjugated
Produktnummer ABIN968565
  • Target Alle IGFBP3 Antikörper anzeigen
    IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))
    Bindungsspezifität
    • 15
    • 11
    • 9
    • 8
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 101-210
    Reaktivität
    • 100
    • 42
    • 33
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 102
    • 14
    • 1
    • 1
    Maus
    Klonalität
    • 103
    • 15
    Monoklonal
    Konjugat
    • 62
    • 15
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IGFBP3 Antikörper ist unkonjugiert
    Applikation
    • 101
    • 48
    • 46
    • 17
    • 13
    • 13
    • 8
    • 7
    • 7
    • 5
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human IGFBP-3 aa. 101-210
    Klon
    4-IGFBP
    Isotyp
    IgG1
    Top Product
    Discover our top product IGFBP3 Primärantikörper
  • Kommentare

    Related Products: ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Campbell, Durham, Hayes, Suwanichkul, Powell: "Insulin-like growth factor-binding protein-3 binds fibrinogen and fibrin." in: The Journal of biological chemistry, Vol. 274, Issue 42, pp. 30215-21, (1999) (PubMed).

    Janosi, Firth, Bond, Baxter, Delhanty: "N-Linked glycosylation and sialylation of the acid-labile subunit. Role in complex formation with insulin-like growth factor (IGF)-binding protein-3 and the IGFs." in: The Journal of biological chemistry, Vol. 274, Issue 9, pp. 5292-8, (1999) (PubMed).

    Shang, Baumrucker, Green: "Signal relay by retinoic acid receptors alpha and beta in the retinoic acid-induced expression of insulin-like growth factor-binding protein-3 in breast cancer cells." in: The Journal of biological chemistry, Vol. 274, Issue 25, pp. 18005-10, (1999) (PubMed).

    Cubbage, Suwanichkul, Powell: "Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity." in: The Journal of biological chemistry, Vol. 265, Issue 21, pp. 12642-9, (1990) (PubMed).

  • Target
    IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))
    Andere Bezeichnung
    IGFBP-3 (IGFBP3 Produkte)
    Synonyme
    BP-53 antikoerper, IBP3 antikoerper, AI649005 antikoerper, IGFBP-3 antikoerper, IGgfbp3 antikoerper, IGF-BP3 antikoerper, zgc:91788 antikoerper, IGFBP3 antikoerper, igfbp3 antikoerper, insulin like growth factor binding protein 3 antikoerper, insulin-like growth factor binding protein 3 antikoerper, IGFBP3 antikoerper, Igfbp3 antikoerper, igfbp3 antikoerper, IGFBP-3 antikoerper, LOC100305016 antikoerper
    Hintergrund
    Insulin-like growth factors (IGF) I and II are peptide hormones that regulate cellular proliferation and differentiation. Most circulating IGFs exist in 130-150 kDa ternary complexes containing IGF-Binding Protein-3 (IGFBP-3) and an 85 kDa glycoprotein, the acid-labile subunit (ALS). IGFBP-3 is one of six IGFBPs that, by binding IGF peptides, prolong their half life and maintain the IGF reservoir. IGFBP-3 is found in body fluids as multiple 40-50 kDa forms as a result of differential glycosylation. The expression of IGFBP-3 in many tissues suggests that it locally modulates the autocrine/paracrine action of IGF peptides. IGFBP-3 binding to fibrinogen may be important for wound healing, since this concentrates IGF-I at wound sites and lowers the affinity of IGF-I for IGFBP-3. In addition, retinoic acid-induced IGFBP-3 expression inhibits the growth promoting effects of IGF-I in breast cancer cells. This may link the retinoid and IGF systems in cell growth regulation and explain how the loss of retinoic acid receptor beta leads to breast cancer progression. Thus, IGFBP-3 maintenance and regulation of IGF activity in various tissues may have diverse physiological roles.
    Synonyms: IGF-Binding Protein-3
    Molekulargewicht
    40 & 44 kDa
    Pathways
    Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagie, Smooth Muscle Cell Migration, Growth Factor Binding
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