Tyrosinase-Related Protein 1 Antikörper (CF®740)

Produktnummer ABIN7661517

Dieses Anti-Tyrosinase-Related Protein 1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Tyrosinase-Related Protein 1 in . Geeignet für Human und Maus.

Kurzübersicht für Tyrosinase-Related Protein 1 Antikörper (CF®740) (ABIN7661517)

Target: Tyrosinase-Related Protein 1 (TYRP1)

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Tyrosinase-Related Protein 1 Antikörper ist konjugiert mit CF®740

Applikation: Bitte anfragen

Klon: TA99 TYRP1-807

Produktdetails anti-Tyrosinase-Related Protein 1 Antikörper (CF®740)

Verwendungszweck: TRP1 (Tyrosinase Related Protein 1) (TA99 + TYRP1/807), CF740 conjugate

Produktmerkmale: This antibody reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: SK-MEL-23 cells (TA99), Recombinant full-length human TYRP1 protein (TYRP1/807)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Not suitable for FFPE sections. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry

Kommentare:

Positive Control: SK-MEL-23, SK-MEL-19, SK-MEL-30 cells or Melanoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % rBSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Andere Bezeichnung: TRP1

Hintergrund:

Synonyms: 5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75, Tyrosinase-related protein 1 (TYRP1), TYRRP

Gene Symbol: TYRP1

Tissue Expression: Melanocytes

Molekulargewicht: 75 kDa

Gen-ID: 7306

UniProt: P17643