Tyrosinase-Related Protein 1 Antikörper (AA 257-377) (CF®647)

Produktnummer ABIN7661505

Dieses Anti-Tyrosinase-Related Protein 1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Tyrosinase-Related Protein 1 in IHC und IHC (fp). Geeignet für Human.

Kurzübersicht für Tyrosinase-Related Protein 1 Antikörper (AA 257-377) (CF®647) (ABIN7661505)

Target: Tyrosinase-Related Protein 1 (TYRP1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Tyrosinase-Related Protein 1 Antikörper ist konjugiert mit CF®647

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: TYRP1-3283

Produktdetails anti-Tyrosinase-Related Protein 1 Antikörper (CF®647)

Bindungsspezifität: AA 257-377

Verwendungszweck: Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker)(TYRP1/3283), CF647 conjugate

Produktmerkmale: Reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: A recombinant fragment (around aa 257-377) of human TYRP1 protein

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells. Human Skin or Melanoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Andere Bezeichnung: Tyrosinase Related Protein-1

Hintergrund:

Synonyms: 5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75

Gene Symbol: TYRP1

Tissue Expression: Melanocytes

Molekulargewicht: 75 kDa

Gen-ID: 7306

UniProt: P17643