PDGFA Antikörper (AA 87-211)

Produktnummer ABIN7602580

Der Kaninchen Polyklonal Anti-PDGFA-Antikörper wurde für WB, ELISA, ICC und IF validiert. Er ist geeignet, PDGFA in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für PDGFA Antikörper (AA 87-211) (ABIN7602580)

Target: PDGFA (Platelet Derived Growth Factor A (PDGFA))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDGFA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-PDGFA Antikörper

Bindungsspezifität: AA 87-211

Verwendungszweck: Anti-PDGF AA/PDGFA Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-PDGF AA/PDGFA Antibody Picoband® (ABIN7602580). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PDGF AA/PDGFA recombinant protein (Position: S87-T211).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Beckmann, M. P., Betsholtz, C., Heldin, C.-H., Westermark, B., Di Marco, E., Di Fiore, P. P., Robbins, K. C., Aaronson, S. A. Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Science 241: 1346-1349, 1988. 2. Betsholtz, C., Johnsson, A., Heldin, C.-H., Westermark, B., Lind, P., Urdea, M. S., Eddy, R., Shows, T. B., Philpott, K., Mellor, A. L., Knott, T. J., Scott, J. cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature 320: 695-699, 1986. 3. Bonthron, D., Collins, T., Grzeschik, K.-H., van Roy, N., Speleman, F. Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite. Genomics 13: 257-263, 1992.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu PDGFA

Target: PDGFA (Platelet Derived Growth Factor A (PDGFA))

Andere Bezeichnung: PDGFA

Hintergrund:

Synonyms: Mitochondrial uncoupling protein 2,UCP 2,Solute carrier family 25 member 8,UCPH,UCP2,SLC25A8,

Tissue Specificity: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.

Background: Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene. This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 24 kDa

Gen-ID: 5154

UniProt: P04085

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling