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CARD9 Antikörper (AA 1-429)

Der Kaninchen Polyklonal Anti-CARD9-Antikörper wurde für WB, IHC, ELISA, ICC, IF und FACS validiert. Er ist geeignet, CARD9 in Proben von Human zu detektieren.
Produktnummer ABIN7599386

Kurzübersicht für CARD9 Antikörper (AA 1-429) (ABIN7599386)

Target

Alle CARD9 Antikörper anzeigen
CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))

Reaktivität

  • 45
  • 5
  • 3
  • 2
  • 2
  • 1
Human

Wirt

  • 44
  • 3
Kaninchen

Klonalität

  • 45
  • 2
Polyklonal

Konjugat

  • 27
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CARD9 Antikörper ist unkonjugiert

Applikation

  • 40
  • 13
  • 13
  • 12
  • 10
  • 9
  • 7
  • 7
  • 3
  • 3
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 15
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-429

    Verwendungszweck

    Anti-CARD9 Picoband® Antibody

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-CARD9 Picoband® Antibody (ABIN7599386). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human CARD9 recombinant protein (Position: M1-D429).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Hsu, Y.-M. S., Zhang, Y., You, Y., Wang, D., Li, H., Duramad, O., Qin, X.-F., Dong, C., Lin, X. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nature Immun. 8: 198-205, 2007. 2. Lanternier, F., Pathan, S., Vincent, Q. B., Liu, L., Cypowyj, S., Prando, C., Migaud, M., Taibi, L., Ammar-Khodja, A., Boudghene Stambouli, O., Guellil, B., Jacobs, F., and 21 others. Deep dermatophytosis and inherited CARD9 deficiency. New Eng. J. Med. 369: 1704-1714, 2013. 3. Yang, H., Minamishima, Y. A., Yan, Q., Schlisio, S., Ebert, B. L., Zhang, X., Zhang, L., Kim, W. Y., Olumi, A. F., Kaelin, W. G., Jr. pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappa-B agonist Card9 by CK2. Molec. Cell 28: 15-27, 2007.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))

    Andere Bezeichnung

    CARD9

    Hintergrund

    Synonyms: Caspase recruitment domain-containing protein 9. Hcard9. CARD9

    Tissue Specificity: Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.

    Background: Caspase recruitment domain-containing protein 9 is an adaptor protein of the CARD-CC protein family, which in humans is encoded by the CARD9 gene. It is mapped to 9q34.3. The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined.

    Molekulargewicht

    63 kDa

    Gen-ID

    64170

    UniProt

    Q9H257

    Pathways

    Activation of Innate immune Response
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