XPC Antikörper

Produktnummer ABIN7469198

Dieses Anti-XPC-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von XPC in WB, ICC, IHC (p) und IF. Geeignet für Human.

Kurzübersicht für XPC Antikörper (ABIN7469198)

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser XPC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Klon: 3-26

Produktdetails anti-XPC Antikörper

Kreuzreaktivität: Human, Maus

Aufreinigung: Protein G purified

Immunogen: Recombinant XPC purified from E. coli

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: HeLa whole cell extract

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.15 mg/mL

Buffer: PBS, No Preservative

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu XPC

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Andere Bezeichnung: XPC complex subunit, DNA damage recognition and repair factor

Hintergrund:

Synonyms: XPC complex subunit, DNA damage recognition and repair factor , RAD4 , XP3 , XPCC , p125

Background: The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]

Molekulargewicht: 106 kDa

Gen-ID: 7508

UniProt: Q01831

Pathways: p53 Signalweg, DNA Reparatur