BRCA2 Antikörper (AA 2336-2478)

Produktnummer ABIN7468065

Dieses Maus Monoklonal-Antikörper erkennt spezifisch BRCA2 in WB, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für BRCA2 Antikörper (AA 2336-2478) (ABIN7468065)

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BRCA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 5F6

Produktdetails anti-BRCA2 Antikörper

Bindungsspezifität: AA 2336-2478

Kreuzreaktivität: Human

Aufreinigung: Protein G purified

Immunogen: Amino acids 2336-2478 of human BRCA2 expressed in E. coli. BRCA2-P400.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Do not boil samples for longer than two minutes. For WB: Use at a concentration of 1-5 μg/mL. Predicted molecular weight: 380 kDa. Optimal dilutions/concentrations should be determined by the reseracher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, No Preservative

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu BRCA2

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Andere Bezeichnung: BRCA2 DNA repair associated

Hintergrund:

Synonyms: BRCA2 DNA repair associated , BRCC2 , BROVCA2 , FACD , FAD , FAD1 , FANCD , FANCD1 , GLM3 , PNCA2 , XRCC11

Background: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]

Molekulargewicht: 384 kDa

Gen-ID: 675

UniProt: P51587

Pathways: DNA Reparatur, M Phase, Maintenance of Protein Location