ATR Antikörper (AA 710-1100)

Produktnummer ABIN7467985

Der Maus Monoklonal Anti-ATR-Antikörper wurde für WB, IP, ICC, IF und Func validiert. Er ist geeignet, ATR in Proben von Human zu detektieren.

Kurzübersicht für ATR Antikörper (AA 710-1100) (ABIN7467985)

Target: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Functional Studies (Func)

Klon: 2B5

Produktdetails anti-ATR Antikörper

Bindungsspezifität: AA 710-1100

Kreuzreaktivität: Human, Maus

Aufreinigung: Protein G purified

Immunogen: Recombinant fragment, corresponding to amino acids 710-1100 of Human ATR.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: Raji , Raji nuclear extract Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, No Preservative

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu ATR

Target: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Andere Bezeichnung: ATR serine/threonine kinase

Hintergrund:

Synonyms: ATR serine/threonine kinase , FCTCS , FRP1 , MEC1 , SCKL , SCKL1

Background: The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]

Molekulargewicht: 301 kDa

Gen-ID: 545

UniProt: Q13535

Pathways: p53 Signalweg, Apoptose, DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus