ATR Antikörper (pThr1989)

Produktnummer ABIN7467984

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ATR in WB, IP, ICC und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ATR Antikörper (pThr1989) (ABIN7467984)

Target: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)

Klon: GT222

Produktdetails anti-ATR Antikörper

Bindungsspezifität: pThr1989

Kreuzreaktivität: Human

Aufreinigung: Affinity purified by Protein A.

Immunogen: Carrier-protein conjugated synthetic peptide surrounding phospho Thr1989 of human ATR. The exact sequence is proprietary.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: HCT116 , HCT116(100 J/m2 UVC and recover for 6hr) Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, No Preservative

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu ATR

Target: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Andere Bezeichnung: ATR serine/threonine kinase

Hintergrund:

Synonyms: ATR serine/threonine kinase , FCTCS , FRP1 , MEC1 , SCKL , SCKL1

Background: The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq]

Molekulargewicht: 301 kDa

Gen-ID: 545

UniProt: Q13535

Pathways: p53 Signalweg, Apoptose, DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus