SARM1 Antikörper (C-Term)

Produktnummer ABIN7466589

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SARM1 in WB, IF und ICC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SARM1 Antikörper (C-Term) (ABIN7466589)

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SARM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Güteklasse: KO Validated

Produktdetails anti-SARM1 Antikörper

Bindungsspezifität: C-Term

Spezifität: Knockdown/Knockout validation was supported by references (PMID:36055989)

Kreuzreaktivität: Drosophila melanogaster, Human, Maus

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human SARM1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Validation: KO/KD, Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.4 mg/mL

Buffer: 1XPBS pH 7, 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu SARM1

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Andere Bezeichnung: sterile alpha and TIR motif containing 1

Hintergrund: Sterile alpha and TIR motif containing 1 , MyD88-5 , SAMD2 , SARM,Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.

Molekulargewicht: 79 kDa

Gen-ID: 23098

UniProt: Q6SZW1

Pathways: TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades