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Caspase 1 Antikörper (Cleaved-Asp297)

Der Kaninchen Polyklonal Anti-Caspase 1-Antikörper wurde für WB validiert. Er ist geeignet, Caspase 1 in Proben von Human zu detektieren.
Produktnummer ABIN7464949

Kurzübersicht für Caspase 1 Antikörper (Cleaved-Asp297) (ABIN7464949)

Target

Alle Caspase 1 (CASP1) Antikörper anzeigen
Caspase 1 (CASP1)

Reaktivität

  • 108
  • 40
  • 35
  • 7
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 127
  • 12
  • 4
  • 1
Kaninchen

Klonalität

  • 116
  • 28
Polyklonal

Konjugat

  • 97
  • 23
  • 9
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser Caspase 1 Antikörper ist unkonjugiert

Applikation

  • 115
  • 72
  • 47
  • 32
  • 24
  • 21
  • 20
  • 5
  • 4
  • 3
  • 3
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 11
    • 9
    • 8
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cleaved-Asp297

    Kreuzreaktivität

    Human

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Caspase 1 (cleaved Asp297) . The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Kommentare

    Positive Control: THP-1 conditioned medium (500 ng/ml LPS treatment for 4 hr in serum free and 1 mM ATP treatment for 1.5 hr)

    Validation: Comparison, Orthogonal

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    Caspase 1 (CASP1)

    Andere Bezeichnung

    caspase 1

    Hintergrund

    Caspase 1 , ICE , IL1BC , P45,This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]

    Molekulargewicht

    45 kDa

    Gen-ID

    834

    UniProt

    P29466

    Pathways

    Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome
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