SQSTM1 Antikörper

Produktnummer ABIN7464360

Dieses Maus Monoklonal-Antikörper erkennt spezifisch SQSTM1 in WB, IF und ICC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SQSTM1 Antikörper (ABIN7464360)

Target: SQSTM1 (Sequestosome 1 (SQSTM1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SQSTM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Güteklasse: KO Validated

Klon: GT381

Produktdetails anti-SQSTM1 Antikörper

Kreuzreaktivität: Human

Aufreinigung: Affinity purified by Protein G.

Immunogen: Recombinant protein encompassing a sequence within the center region of human SQSTM1 / P62. The exact sequence is proprietary.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: A549 , H1299 , Huh-7 (3 μM Thapsigargin treatment for 12 hr) , Huh-7 (3 μM Thapsigargin treatment for 24 hr) , HepG2 (3 μM Thapsigargin treatment for 12 hr) , HepG2 (3 μM Thapsigargin treatment for 24 hr)

Validation: KO/KD, Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, No Preservative

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu SQSTM1

Target: SQSTM1 (Sequestosome 1 (SQSTM1))

Andere Bezeichnung: sequestosome 1

Hintergrund: Sequestosome 1 , A170 , DMRV , FTDALS3 , NADGP , OSIL , PDB3 , ZIP3 , p60 , p62 , p62B,This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq]

Molekulargewicht: 48 kDa

Gen-ID: 8878

UniProt: Q13501

Pathways: NF-kappaB Signalweg, Neurotrophin Signalübertragung, Autophagie