TDG Antikörper (AA 360-410)
Kurzübersicht für TDG Antikörper (AA 360-410) (ABIN7455026)
Target
Alle TDG Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 360-410
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Verwendungszweck
- Rabbit anti-TDG Antibody, Affinity Purified
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Aufreinigung
- Affinity Purified
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Immunogen
- Between AA 360 and 410
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Isotyp
- IgG
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Applikationshinweise
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- TDG (Thymine-DNA Glycosylase (TDG))
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Andere Bezeichnung
- TDG
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Hintergrund
- Background: Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine [taken from NCBI Entrez Gene (Gene ID: 6996)].
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Gen-ID
- 6996
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NCBI Accession
- NP_003202
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UniProt
- Q13569
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Pathways
- DNA Reparatur, Chromatin Binding
Target
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