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LIN28B Antikörper (AA 200-250)

LIN28B Reaktivität: Human IP, IHC (fp) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7454493
  • Target Alle LIN28B Antikörper anzeigen
    LIN28B (Lin-28 Homolog B (LIN28B))
    Bindungsspezifität
    • 8
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 200-250
    Reaktivität
    • 44
    • 9
    • 2
    • 1
    Human
    Wirt
    • 43
    • 1
    • 1
    Kaninchen
    Klonalität
    • 42
    • 3
    Polyklonal
    Konjugat
    • 29
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LIN28B Antikörper ist unkonjugiert
    Applikation
    • 30
    • 20
    • 19
    • 19
    • 18
    • 6
    • 5
    • 3
    • 3
    Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
    Verwendungszweck
    Rabbit anti-LIN28B Antibody, Affinity Purified
    Aufreinigung
    Affinity Purified
    Immunogen
    Between AA 200 and 250
    Isotyp
    IgG
    Top Product
    Discover our top product LIN28B Primärantikörper
  • Applikationshinweise

    IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

    IP: 2 - 10 μg/mg lysate

    WB: Not recommended

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1000 μg/mL
    Buffer
    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Haltbarkeit
    12 months
  • Target
    LIN28B (Lin-28 Homolog B (LIN28B))
    Andere Bezeichnung
    LIN28B (LIN28B Produkte)
    Hintergrund
    Background: Lin-28 homolog B (LIN28B) acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. LIN28B acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. LIN28B specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. It also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation [taken from the Universal Protein Resource (UniProt) Q6ZN17].
    Gen-ID
    389421
    NCBI Accession
    NP_001004317
    UniProt
    Q6ZN17
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