LIN28B Antikörper (AA 200-250)
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- Target Alle LIN28B Antikörper anzeigen
- LIN28B (Lin-28 Homolog B (LIN28B))
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Bindungsspezifität
- AA 200-250
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser LIN28B Antikörper ist unkonjugiert
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Applikation
- Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
- Verwendungszweck
- Rabbit anti-LIN28B Antibody, Affinity Purified
- Aufreinigung
- Affinity Purified
- Immunogen
- Between AA 200 and 250
- Isotyp
- IgG
- Top Product
- Discover our top product LIN28B Primärantikörper
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- Applikationshinweise
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
WB: Not recommended
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1000 μg/mL
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Haltbarkeit
- 12 months
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- Target
- LIN28B (Lin-28 Homolog B (LIN28B))
- Andere Bezeichnung
- LIN28B (LIN28B Produkte)
- Hintergrund
- Background: Lin-28 homolog B (LIN28B) acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. LIN28B acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. LIN28B specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. It also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation [taken from the Universal Protein Resource (UniProt) Q6ZN17].
- Gen-ID
- 389421
- NCBI Accession
- NP_001004317
- UniProt
- Q6ZN17
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