LIN28B Antikörper (AA 200-250)
Kurzübersicht für LIN28B Antikörper (AA 200-250) (ABIN7454493)
Target
Alle LIN28B Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- AA 200-250
-
Verwendungszweck
- Rabbit anti-LIN28B Antibody, Affinity Purified
-
Aufreinigung
- Affinity Purified
-
Immunogen
- Between AA 200 and 250
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
-
IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
WB: Not recommended
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Konzentration
- 1000 μg/mL
-
Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- 4 °C
-
Haltbarkeit
- 12 months
-
-
- LIN28B (Lin-28 Homolog B (LIN28B))
-
Andere Bezeichnung
- LIN28B
-
Hintergrund
- Background: Lin-28 homolog B (LIN28B) acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. LIN28B acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. LIN28B specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. It also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation [taken from the Universal Protein Resource (UniProt) Q6ZN17].
-
Gen-ID
- 389421
-
NCBI Accession
- NP_001004317
-
UniProt
- Q6ZN17
Target
-