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LIN28B Antikörper (AA 95-128)

LIN28B Reaktivität: Human WB, FACS, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5536364
  • Target Alle LIN28B Antikörper anzeigen
    LIN28B (Lin-28 Homolog B (LIN28B))
    Bindungsspezifität
    • 11
    • 9
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 95-128
    Reaktivität
    • 56
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 55
    • 1
    • 1
    Kaninchen
    Klonalität
    • 54
    • 3
    Polyklonal
    Konjugat
    • 35
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LIN28B Antikörper ist unkonjugiert
    Applikation
    • 42
    • 28
    • 26
    • 24
    • 22
    • 7
    • 6
    • 4
    • 4
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This LIN28B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-128 amino acids from the Central region of human LIN28B.
    Isotyp
    Ig Fraction
  • Applikationshinweise
    For IHC-P starting dilution is: 1:25

    For WB starting dilution is: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.33 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    LIN28B (Lin-28 Homolog B (LIN28B))
    Andere Bezeichnung
    LIN28B (LIN28B Produkte)
    Synonyme
    csdd2 antikoerper, LIN-28 antikoerper, CSDD2 antikoerper, 2810403D23Rik antikoerper, D030047M17Rik antikoerper, Lin-28.2 antikoerper, lin-28 homolog B antikoerper, lin-28 homolog B S homeolog antikoerper, lin-28 homolog B (C. elegans) antikoerper, LIN28B antikoerper, lin28b antikoerper, lin28b.S antikoerper, Lin28b antikoerper
    Hintergrund
    Lin-28 homolog B (LIN28B) is overexpressed in hepatocellular carcinoma. The heterochronic gene lin-28 is a key regulator of developmental timing in the nematode Caenorhabditis elegans. Similar with lin-28 proteins, LIN28B conserves a cold shock domain and a pair of CCHC zinc finger domains. Phylogenetic analysis suggests that they might arise as a result of duplication from an ancestral gene. Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. A short LIN28B isoform was also identified in non-tumor liver tissue and fetal liver. Although predominantly localized in the cytoplasm, LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells. Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation.
    Molekulargewicht
    27 kDa
    Gen-ID
    389421
    UniProt
    Q6ZN17
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