ERCC3 Antikörper (AA 575-625)

Produktnummer ABIN7454400

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ERCC3 in IP und IHC (fp). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ERCC3 Antikörper (AA 575-625) (ABIN7454400)

Target: ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERCC3 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-ERCC3 Antikörper

Bindungsspezifität: AA 575-625

Verwendungszweck: Rabbit anti-ERCC3 Antibody, Affinity Purified

Homologie: Mouse,Rat,Zebrafish,Bovine,Orangutan

Aufreinigung: Affinity Purified

Immunogen: between AA 575 and 625

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:2,000 to 1:10,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-ERCC3 antibody A301-337A.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu ERCC3

Target: ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))

Andere Bezeichnung: ERCC3

Hintergrund: Background: ERCC3 is a component of the core TFIIH basal transcription factor and functions as an ATP-dependent 3'-5' DNA helicase. ERCC3 is involved in nucleotide excision repair and is the cause of xeroderma pigmentosum complementation group B (XPB), also known as xeroderma pigmentosum II (XP2). Additionally, it has been found to be the cuase of Cockayne syndrome, and trichothiodystrophy (TTD). XPB is an autosomal recessive disease characterized by skin photosensitivity and a predisposition to skin cancer, and neurological abnormalities. Cockayne syndrome and TTD are similarly characterized by photosensitivity and neural abnormalities.

Gen-ID: 2071

NCBI Accession: NP_000113

UniProt: P19447

Pathways: DNA Reparatur