Rekombinanter EPAS1 Antikörper (AA 400-450)

Produktnummer ABIN7454018

Dieses Anti-EPAS1-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von EPAS1 in WB, IHC, IP, ICC, IF/ICC und ChIP-seq. Geeignet für Human.

Kurzübersicht für Rekombinanter EPAS1 Antikörper (AA 400-450) (ABIN7454018)

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser EPAS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (fixed cells) (IF/ICC), ChIP DNA-Sequencing (ChIP-seq)

Klon: BL-95-1A2

Produktdetails anti-EPAS1 Antikörper

Bindungsspezifität: AA 400-450

Verwendungszweck: Rabbit anti-HIF2-alpha Recombinant Monoclonal Antibody [BL-95-1A2]

Immunogen: between AA 400 and 450

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.09 % Sodium Azide, BSA-Free

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu EPAS1

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Andere Bezeichnung: HIF2-alpha

Hintergrund: Background: The gene EPAS1 encodes for the transcription factor endothelial PAS domain-containing protein 1, and is induced as oxygen levels fall. Commonly called hypoxia inducible factor 2A (HIF2a), this protein is involved in the induction of oxygen regulated genes, binding to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. An important cancer biomarker, HIF2a may also play a role in Tibetan high-altitude adaptation (Am J Hum Genet. 2015 Jul 2, 97(1): 54-66.) and mutations in the EPAS1 gene are associated with erythrocytosis familial type 4 [taken from NCBI Entrez Gene (Gene ID: 2034) and UniProtKB (Entry: Q99814)].

Gen-ID: 2034

NCBI Accession: NP_001421

UniProt: Q99814

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effekt