TOPBP1 Antikörper (C-Term)
Kurzübersicht für TOPBP1 Antikörper (C-Term) (ABIN7452107)
Target
Alle TOPBP1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- C-Term
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Verwendungszweck
- Rabbit anti-TopBP1 Antibody, Affinity Purified
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 1400 and C-term
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Isotyp
- IgG
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anti-Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) (AA 1253-1522) antibody
TOPBP1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) (AA 1-100) antibodyTOPBP1 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) (AA 1327-1435) antibodyTOPBP1 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 6D12 unconjugated
anti-Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) (AA 1-250) antibodyTOPBP1 Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) (AA 1-246) antibodyTOPBP1 Reaktivität: Maus WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) (AA 1253-1522) antibodyTOPBP1 Reaktivität: Human IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) (pSer1159) antibodyTOPBP1 Reaktivität: Human DB Wirt: Kaninchen Polyclonal RB36342 unconjugated
anti-Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) (AA 204-416) antibodyTOPBP1 Reaktivität: Human WB, IF Wirt: Maus Monoclonal 33-TopBP1 unconjugated
anti-Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) (Internal Region) antibodyTOPBP1 Reaktivität: Human, Maus WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) (pSer1138) antibodyTOPBP1 Reaktivität: Human DB Wirt: Kaninchen Polyclonal RB36322 unconjugated
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Applikationshinweise
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IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))
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Andere Bezeichnung
- TopBP1
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Hintergrund
- Background: Topoisomerases regulate topological states of DNA. DNA topoisomerase II-binding protein 1 (TopBP1) is a protein that interacts with the C-terminal region of topoisomerase II beta (Topo II beta). TopBP1 function has been found to be important to various aspects of cellular growth control such as DNA replication, the DNA damage checkpoint, and cell survival. TopBP1 interacts with several proteins through its BRCA1 C-terminal (BRCT) motifs. TopBP1 interacts and inhibits E2F1 transcriptional activity through an Rb-independent mechanism that involves recruitment of the SWI/SNF chromatin-remodeling complex proteins Brg1 and Brm.
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Gen-ID
- 11073
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NCBI Accession
- NP_008958
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UniProt
- Q92547
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Pathways
- Chromatin Binding
Target
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