TOPBP1 Antikörper (AA 1253-1522)

Produktnummer ABIN7150350

Produktdetails anti-TOPBP1 Antikörper

Target: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Bindungsspezifität: AA 1253-1522

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TOPBP1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human DNA topoisomerase 2-binding protein 1 protein (1253-1522AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TOPBP1

Target: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Andere Bezeichnung: TOPBP1 (TOPBP1 Produkte)

Synonyme: RGD1562949 antikoerper, TOPBP1 antikoerper, cut5 antikoerper, F2P24.3 antikoerper, F2P24_3 antikoerper, meiosis defective 1 antikoerper, TOP2BP1 antikoerper, 1110031N14Rik antikoerper, 2810429C13Rik antikoerper, AI256758 antikoerper, D430026L04Rik antikoerper, mKIAA0259 antikoerper, TopBP1-A antikoerper, TopBP1-B antikoerper, Xmus101 antikoerper, XtopBP antikoerper, mus101 antikoerper, top2bp1 antikoerper, DNA topoisomerase II binding protein 1 antikoerper, topoisomerase (DNA) II binding protein 1 antikoerper, dna topoisomerase ii binding protein 1 (IC) antikoerper, transcription coactivator antikoerper, DNA topoisomerase II binding protein 1 L homeolog antikoerper, Topbp1 antikoerper, topbp1 antikoerper, TOPBP1 antikoerper, MEI1 antikoerper, topbp1.L antikoerper

Hintergrund:

Background: Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.

Aliases: DNA topoisomerase 2 binding protein 1 antibody, DNA topoisomerase 2-binding protein 1 antibody, DNA topoisomerase II binding protein 1 antibody, DNA topoisomerase II binding protein antibody, DNA topoisomerase II-beta-binding protein 1 antibody, DNA topoisomerase II-binding protein 1 antibody, DNA topoisomerase IIbeta binding protein 1 antibody, Hypothetical protein KIAA0259 [Fragment] antibody, KIAA0259 antibody, TOP2BP1 antibody, TOPB1_HUMAN antibody, TOPBP 1 antibody, TopBP1 antibody, Topoisomerase (DNA) II binding protein 1 antibody, Topoisomerase II binding protein 1 antibody

UniProt: Q92547

Pathways: Chromatin Binding