TOPBP1 Antikörper (pSer1159)
Kurzübersicht für TOPBP1 Antikörper (pSer1159) (ABIN1539690)
Target
Alle TOPBP1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- pSer1159
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Homologie
- M
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Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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Immunogen
- This TOPBP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1159 of human TOPBP1.
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Isotyp
- Ig Fraction
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Applikationshinweise
- DB: 1:500
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Phospho-TOPBP1-S1159 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the Phospho-TOPBP1-S1159 Antibody at -20 °C.
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Haltbarkeit
- 6 months
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: "Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization." in: Molecular and cellular biology, Vol. 33, Issue 23, pp. 4685-700, (2013) (PubMed).
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- TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))
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Andere Bezeichnung
- TOPBP1
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Hintergrund
- This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.
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Molekulargewicht
- 170679
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Gen-ID
- 11073
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NCBI Accession
- NP_008958
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UniProt
- Q92547
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Pathways
- Chromatin Binding
Target
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