TOPBP1 Antikörper (Internal Region)

Produktnummer ABIN6265675

Produktdetails anti-TOPBP1 Antikörper

Target: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TOPBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: TOPBP1 Antibody detects endogenous levels of total TOPBP1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TOPBP1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu TOPBP1

Target: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Andere Bezeichnung: TOPBP1 (TOPBP1 Produkte)

Synonyme: RGD1562949 antikoerper, TOPBP1 antikoerper, cut5 antikoerper, F2P24.3 antikoerper, F2P24_3 antikoerper, meiosis defective 1 antikoerper, TOP2BP1 antikoerper, 1110031N14Rik antikoerper, 2810429C13Rik antikoerper, AI256758 antikoerper, D430026L04Rik antikoerper, mKIAA0259 antikoerper, TopBP1-A antikoerper, TopBP1-B antikoerper, Xmus101 antikoerper, XtopBP antikoerper, mus101 antikoerper, top2bp1 antikoerper, DNA topoisomerase II binding protein 1 antikoerper, topoisomerase (DNA) II binding protein 1 antikoerper, dna topoisomerase ii binding protein 1 (IC) antikoerper, transcription coactivator antikoerper, DNA topoisomerase II binding protein 1 L homeolog antikoerper, Topbp1 antikoerper, topbp1 antikoerper, TOPBP1 antikoerper, MEI1 antikoerper, topbp1.L antikoerper

Hintergrund:

Description: Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042).

Gene: TOPBP1

Molekulargewicht: 173kDa

Gen-ID: 11073

UniProt: Q92547

Pathways: Chromatin Binding