XBP1 Antikörper

Produktnummer ABIN7384507

Dieses Anti-XBP1-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von XBP1 in WB. Geeignet für Human und Maus.

Kurzübersicht für XBP1 Antikörper (ABIN7384507)

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser XBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: R04-3E2

Produktdetails anti-XBP1 Antikörper

Aufreinigung: Affinity Purified

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu XBP1

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Andere Bezeichnung: XBP1

Hintergrund: Tax responsive element binding protein 5,Tax-responsive element-binding protein 5,TREB5,X box binding protein 1,X box binding protein 2,X-box-binding protein 1,XBP 1,XBP-1,XBP1,XBP1,XBP2,This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor.

Molekulargewicht:

Observed_MW: 29kDa

Calculated_MW: 29kDa

Gen-ID: 7494

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response