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Adenosine A3 Receptor Antikörper (Extracellular)

Dieses Anti-Adenosine A3 Receptor-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Adenosine A3 Receptor in WB, FACS und LCI. Geeignet für Maus.
Produktnummer ABIN7237577

Kurzübersicht für Adenosine A3 Receptor Antikörper (Extracellular) (ABIN7237577)

Target

Alle Adenosine A3 Receptor (ADORA3) Antikörper anzeigen
Adenosine A3 Receptor (ADORA3)

Reaktivität

  • 31
  • 14
  • 7
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Maus

Wirt

  • 32
  • 2
  • 1
Kaninchen

Klonalität

  • 33
  • 2
Polyklonal

Konjugat

  • 27
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Adenosine A3 Receptor Antikörper ist unkonjugiert

Applikation

  • 21
  • 13
  • 10
  • 8
  • 5
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)
  • Bindungsspezifität

    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 149-161, Extracellular

    Verwendungszweck

    A Rabbit Polyclonal antibody to Adenosine A3 Receptor (extracellular)

    Spezifität

    Extracellular, 2nd loop.

    Kreuzreaktivität

    Maus, Ratte

    Kreuzreaktivität (Details)

    The antibody will not recognize adenosine A3 receptor from human samples.

    Homologie

    Rat - 10 out of 13 amino acid residues identical

    Produktmerkmale

    Extracellular, 2nd loop

    Aufreinigung

    Affinity purified on immobilized antigen.

    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: (C)GWNRKATLASSQN, corresponding to amino acid residues 149 - 161 of mouse ADORA3

    Isotyp

    IgG
  • Applikationshinweise

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

    Application Dilutions Western blot wb: 1:200

    Kommentare

    Negative Control: (ABIN7234643)

    Blocking Peptide: (ABIN7234643)

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

    Konzentration

    1 mg/mL

    Buffer

    PBS pH 7.4

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target

    Adenosine A3 Receptor (ADORA3)

    Andere Bezeichnung

    ADORA3

    Hintergrund

    ADORA3, A3AR, Adenosine Receptor A3,Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including the brain and heart.1,2 Adenosine exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): Adenosine A1 Receptor (A1AR), Adenosine A2A Receptor (A2AAR), Adenosine A2B Receptor (A2BAR), and Adenosine A3 Receptor (A3AR). The various adenosine receptors can be distinguished on the basis of their distinct molecular structures, distinct tissue distributions, and differential selectivity for adenosine analogs.1-4 All are integral membrane proteins and are members of the G protein-coupled receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop important in binding G proteins.1-3Expression of A3AR has been reported in the brain, kidney, liver, and heart. It plays a role in modulation of cerebral ischemia, asthma, and cell growth. In addition, recent studies have established a cardioprotective role for A3AR.5 Expression of A3AR was reported to be elevated in cancerous tissues as well as in auto-immune inflammatory diseases.6,7 A patent has been filed for the use of A3AR and A3AR agonist as a diagnostic marker for therapeutic treatments of cancer and other diseases.ADORA3, A3AR, Adenosine Receptor A3

    Gen-ID

    11542

    UniProt

    Q61618

    Pathways

    Hormone Transport, cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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