Retinoblastoma Binding Protein 8 Antikörper

Produktnummer ABIN7223950

Der Kaninchen Polyklonal Anti-Retinoblastoma Binding Protein 8 Antikörper wurde für ELISA und IHC (p) validiert. Er ist geeignet, Retinoblastoma Binding Protein 8 in Proben von Human und Maus zu detektieren.

Kurzübersicht für Retinoblastoma Binding Protein 8 Antikörper (ABIN7223950)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Retinoblastoma Binding Protein 8 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Retinoblastoma Binding Protein 8 Antikörper

Verwendungszweck: CtIP Polyclonal Antibody

Spezifität: CtIP Polyclonal Antibody detects endogenous levels of CtIP protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human CtIP around the non-phosphorylation site of S327

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Andere Bezeichnung: CtIP

Hintergrund: Rabbit Anti-CtIP Polyclonal Antibody,RBBP8, CTIP, DNA endonuclease RBBP8, CtBP-interacting protein, CtIP, Retinoblastoma-binding protein 8, RBBP-8, Retinoblastoma-interacting protein and myosin-like, RIM, Sporulation in the absence of SPO11 protein 2 homolog, SAE2,The protein encoded by RBBP8 (RB binding protein 8, endonuclease) is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that RBBP8 may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for RBBP8. More transcript variants exist, but their full-length natures have not been determined.,DNA endonuclease RBBP8

Molekulargewicht: observerd band 100kDa

Gen-ID: 5932

UniProt: Q99708

Pathways: Zellzyklus, DNA Reparatur