PTAFR Antikörper (AA 170-250)

Produktnummer ABIN7223724

Der Kaninchen Polyklonal Anti-PTAFR Antikörper wurde für ELISA und IF validiert. Er ist geeignet, PTAFR in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für PTAFR Antikörper (AA 170-250) (ABIN7223724)

Target: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTAFR Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Produktdetails anti-PTAFR Antikörper

Bindungsspezifität: AA 170-250

Verwendungszweck: PAF-R Polyclonal Antibody

Spezifität: PAF-R Polyclonal Antibody detects endogenous levels of PAF-R protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human PAF-R at AA range: 170-250

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.

Kommentare:

Primary Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Details zu PTAFR

Target: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Andere Bezeichnung: PAF-R

Hintergrund: Rabbit Anti-PAF-R Polyclonal Antibody,PTAFR, PAFR, Platelet-activating factor receptor, PAF-R, PAFr,PTAFR (platelet activating factor receptor) encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.,Platelet-activating factor receptor

Gen-ID: 5724

UniProt: P25105

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin