TNFRSF18 Antikörper (AA 184-241)

Produktnummer ABIN7193235

Produktdetails anti-TNFRSF18 Antikörper

Target: TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))

Bindungsspezifität: AA 184-241

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TNFRSF18 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA

Verwendungszweck: GITR Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human GITR (AA: 184-241) expressed in E. Coli.

Klon: 6H8B9

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu TNFRSF18

Target: TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))

Andere Bezeichnung: GITR (TNFRSF18 Produkte)

Hintergrund:

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Molekulargewicht: 26 kDa

Gen-ID: 8784

UniProt: Q9Y5U5

Pathways: Cancer Immune Checkpoints