Src Antikörper (AA 2-146)

Produktnummer ABIN7179842

Produktdetails anti-Src Antikörper

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Bindungsspezifität: AA 2-146

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Src Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Zebrafisch (Danio rerio)

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Zebrafish Proto-oncogene tyrosine-protein kinase Src protein (2-146AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Src

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Andere Bezeichnung: src (Src Produkte)

Synonyme: AW259666 antikoerper, pp60c-src antikoerper, C-src1 antikoerper, CG7524 antikoerper, D-Src64B antikoerper, D-src antikoerper, DSRC64 antikoerper, DSrc antikoerper, DSrc64 antikoerper, DSrc64B antikoerper, Dm SRC1 antikoerper, DmHD-358 antikoerper, Dmel\CG7524 antikoerper, Dsrc antikoerper, Dsrc64 antikoerper, Dsrc64B antikoerper, HD-358 antikoerper, MRE5 antikoerper, SRC 64B antikoerper, Src antikoerper, Src1 antikoerper, Src64 antikoerper, c-src antikoerper, dSrc antikoerper, dsrc antikoerper, src antikoerper, src1 antikoerper, src64 antikoerper, src64B antikoerper, src64b antikoerper, ASV antikoerper, SRC1 antikoerper, c-SRC antikoerper, p60-Src antikoerper, c-Src antikoerper, PP60C-SCR antikoerper, SDR antikoerper, SRC proto-oncogene, non-receptor tyrosine kinase antikoerper, uncharacterized LOC5574802 antikoerper, proto-oncogene tyrosine-protein kinase src antikoerper, Rous sarcoma oncogene antikoerper, Src oncogene at 64B antikoerper, SRC antikoerper, LOC5574802 antikoerper, CpipJ_CPIJ010659 antikoerper, Src antikoerper, Src64B antikoerper

Substanzklasse: Viral Protein

Hintergrund:

Background: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each src kinase is very difficult. Src appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of src to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates involved in this process (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including ptk2/fak1 and paxillin (pxn) (By similarity). Also active at the sites of cell-cell contact adherens junctions and at gap junctions. Implicated in the regulation of pre-mRNA-processing (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Involved in anchorage-independent cell growth (By similarity).

Aliases: src antibody, Proto-oncogene tyrosine-protein kinase Src antibody, EC 2.7.10.2 antibody, Proto-oncogene c-Src antibody, pp60c-src antibody, p60-Src antibody

UniProt: Q1JPZ3

Pathways: JAK-STAT Signalweg, Neurotrophin Signalübertragung, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagie, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling