XBP1 Antikörper (AA 1-167)

Produktnummer ABIN7175883

Der Kaninchen Polyklonal Anti-XBP1-Antikörper wurde für ELISA, IHC und IF validiert. Er ist geeignet, XBP1 in Proben von Human zu detektieren.

Kurzübersicht für XBP1 Antikörper (AA 1-167) (ABIN7175883)

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XBP1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-XBP1 Antikörper

Bindungsspezifität: AA 1-167

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human X-box-binding protein 1 protein (1-167AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu XBP1

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Andere Bezeichnung: XBP1

Hintergrund:

Background: Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity).

Aliases: Tax responsive element binding protein 5 antibody, Tax-responsive element-binding protein 5 antibody, TREB5 antibody, X box binding protein 1 antibody, X box binding protein 2 antibody, X-box-binding protein 1 antibody, XBP 1 antibody, XBP-1 antibody, XBP1 antibody, XBP1_HUMAN antibody, XBP2 antibody

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response