TICAM2 Antikörper (AA 1-235)

Produktnummer ABIN7172205

Der Kaninchen Polyklonal Anti-TICAM2-Antikörper wurde für ELISA und IHC validiert. Er ist geeignet, TICAM2 in Proben von Human zu detektieren.

Kurzübersicht für TICAM2 Antikörper (AA 1-235) (ABIN7172205)

Target: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TICAM2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-TICAM2 Antikörper

Bindungsspezifität: AA 1-235

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human TIR domain-containing adapter molecule 2 protein (1-235AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TICAM2

Target: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Andere Bezeichnung: TICAM2

Hintergrund:

Background: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1, signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB, however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

Aliases: Putative NF-kappa-B-activating protein 502 antibody, TCAM2_HUMAN antibody, TICAM-2 antibody, TICAM2 antibody, TIR containing adapter molecule 2 antibody, TIR domain containing adaptor protein antibody, TIR domain-containing adapter molecule 2 antibody, TIRAP 3 antibody, TIRAP3 antibody, TIRAP3a short form antibody, TIRP antibody, Toll-like receptor adaptor protein 3 antibody, Toll/interleukin-1 receptor domain-containing protein antibody, TRAM antibody, TRIF-related adapter molecule antibody

UniProt: Q86XR7

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades