TICAM2 Antikörper (AA 2-29)

Produktnummer ABIN1169199

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-TICAM2 Antikörper (ABIN1169199) detektiert spezifisch TICAM2 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TICAM2 Antikörper (AA 2-29) (ABIN1169199)

Target: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TICAM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TICAM2 Antikörper

Bindungsspezifität: AA 2-29

Verwendungszweck: anti-TRAM (human), pAb (AL239)

Spezifität: Recognizes human TRAM.

Produktmerkmale: Polyclonal Antibody. Recognizes human TRAM. Source: Rabbit. Applications: WB. Liquid. Neat serum containing 0.02 % sodium azide. TRAM functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. It is also involved in IL-1-triggered NF-kappaB activation, functioning upstream of IRAK1, IRAK2, TRAF6 and IKBKB. TRAM physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TRL4 signal to TICAM-1. It is expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle and pancreas.

Immunogen: Synthetic peptide corresponding to aa 2-29 (G2IGKSKINSCPLSLSWGKRHSVDTSPGY29) of human TRAM.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Neat serum containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-TICAM2 Antikörper (ABIN1169199)

Aksoy, Albarani, Nguyen, Laes, Ruelle, De Wit, Willems, Goldman, Goriely: "Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells." in: Blood, Vol. 109, Issue 7, pp. 2887-93, (2007) (PubMed).

Details zu TICAM2

Target: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Andere Bezeichnung: TRAM

Hintergrund:

Alternate Names/Synonyms: TRIF-related Adapter Molecule, TIRP, Toll-Interleukin 1 Receptor [TIR] Domain-containing Protein, TICAM-2, TIR-containing Adapter Molecule-2

Product Description: TRAM functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. It is also involved in IL-1-triggered NF-kappaB activation, functioning upstream of IRAK1, IRAK2, TRAF6 and IKBKB. TRAM physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TRL4 signal to TICAM-1. It is expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle and pancreas.

UniProt: Q86XR7

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades