PCNA Antikörper (AA 1-261)
Kurzübersicht für PCNA Antikörper (AA 1-261) (ABIN7164738)
Target
Alle PCNA Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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                                            Bindungsspezifität
- AA 1-261
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                                            Kreuzreaktivität
- Human, Maus
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                                            Aufreinigung
- >95%, Protein G purified
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                                            Immunogen
- Recombinant Human Proliferating cell nuclear antigen protein (1-261AA)
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                                            Isotyp
- IgG
 
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                                            Applikationshinweise
- Recommended dilution: WB:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200,
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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                                            Format
- Liquid
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                                            Buffer
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                        Preservative: 0.03 % Proclin 300
 Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
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                                            Konservierungsmittel
- ProClin
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                                            Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            Lagerung
- -20 °C,-80 °C
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                                            Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
 
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    - PCNA (Proliferating Cell Nuclear Antigen (PCNA))
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                                            Andere Bezeichnung
- PCNA
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                                            Hintergrund
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                        Background: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase\'s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3\'-5\' exonuclease and 3\'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while \'Lys-63\'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. Aliases: ATLD2 antibody, cb16 antibody, Cyclin antibody, DNA polymerase delta auxiliary protein antibody, etID36690.10 antibody, fa28e03 antibody, fb36g03 antibody, HGCN8729 antibody, MGC8367 antibody, Mutagen-sensitive 209 protein antibody, OTTHUMP00000030189 antibody, OTTHUMP00000030190 antibody, PCNA antibody, Pcna/cyclin antibody, PCNA_HUMAN antibody, PCNAR antibody, Polymerase delta accessory protein antibody, Proliferating cell nuclear antigen antibody, wu:fa28e03 antibody, wu:fb36g03 antibody 
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                                            UniProt
- P12004
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                                            Pathways
- Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagie
 Target
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