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PCNA Antikörper (AA 1-261)

Der Kaninchen Polyklonal Anti-PCNA-Antikörper wurde für WB, IHC, ELISA und IF validiert. Er ist geeignet, PCNA in Proben von Human zu detektieren.
Produktnummer ABIN7164738

Kurzübersicht für PCNA Antikörper (AA 1-261) (ABIN7164738)

Target

Alle PCNA Antikörper anzeigen
PCNA (Proliferating Cell Nuclear Antigen (PCNA))

Reaktivität

  • 243
  • 166
  • 165
  • 55
  • 32
  • 30
  • 29
  • 22
  • 20
  • 19
  • 18
  • 17
  • 11
  • 10
  • 6
  • 5
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 142
  • 117
  • 3
Kaninchen

Klonalität

  • 139
  • 122
  • 1
Polyklonal

Konjugat

  • 143
  • 17
  • 11
  • 8
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PCNA Antikörper ist unkonjugiert

Applikation

  • 218
  • 79
  • 68
  • 66
  • 65
  • 56
  • 53
  • 46
  • 40
  • 40
  • 15
  • 12
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
  • Bindungsspezifität

    • 16
    • 16
    • 16
    • 15
    • 14
    • 13
    • 12
    • 9
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-261

    Kreuzreaktivität

    Human, Maus

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Proliferating cell nuclear antigen protein (1-261AA)

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: WB:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    PCNA (Proliferating Cell Nuclear Antigen (PCNA))

    Andere Bezeichnung

    PCNA

    Hintergrund

    Background: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase\'s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3\'-5\' exonuclease and 3\'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while \'Lys-63\'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

    Aliases: ATLD2 antibody, cb16 antibody, Cyclin antibody, DNA polymerase delta auxiliary protein antibody, etID36690.10 antibody, fa28e03 antibody, fb36g03 antibody, HGCN8729 antibody, MGC8367 antibody, Mutagen-sensitive 209 protein antibody, OTTHUMP00000030189 antibody, OTTHUMP00000030190 antibody, PCNA antibody, Pcna/cyclin antibody, PCNA_HUMAN antibody, PCNAR antibody, Polymerase delta accessory protein antibody, Proliferating cell nuclear antigen antibody, wu:fa28e03 antibody, wu:fb36g03 antibody

    UniProt

    P12004

    Pathways

    Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagie
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