NOD2 Antikörper (AA 460-733)

Produktnummer ABIN7162073

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NOD2 in ELISA, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für NOD2 Antikörper (AA 460-733) (ABIN7162073)

Target: NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOD2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-NOD2 Antikörper

Bindungsspezifität: AA 460-733

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Nucleotide-binding oligomerization domain-containing protein 2 protein (460-733AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NOD2

Target: NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))

Andere Bezeichnung: NOD2

Hintergrund:

Background: Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).

Aliases: ACUG antibody, Arthrocutaneouveal granulomatosis antibody, BLAU antibody, CARD15 antibody, Caspase recruitment domain family, member 15 antibody, Caspase recruitment domain protein 15 antibody, Caspase recruitment domain-containing protein 15 antibody, CD antibody, CLR16.3 antibody, IBD1 antibody, Inflammatory bowel disease protein 1 antibody, LRR containing protein antibody, NLR family, CARD domain containing 2 antibody, NLRC2 antibody, NOD like receptor C2 antibody, NOD2 antibody, NOD2 protein antibody, NOD2_HUMAN antibody, NOD2B antibody, nucleotide binding oligomerization domain 2 antibody, Nucleotide binding oligomerization domain containing 2 antibody, Nucleotide binding oligomerization domain, leucine rich repeat and CARD domain containing 2 antibody, Nucleotide-binding oligomerization domain-containing protein 2 antibody, PSORAS1 antibody

UniProt: Q9HC29

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome