MYD88 Antikörper (AA 1-282)

Produktnummer ABIN7160472

Der Kaninchen Polyklonal Anti-MYD88-Antikörper wurde für ELISA und IF validiert. Er ist geeignet, MYD88 in Proben von Human zu detektieren.

Kurzübersicht für MYD88 Antikörper (AA 1-282) (ABIN7160472)

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYD88 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Produktdetails anti-MYD88 Antikörper

Bindungsspezifität: AA 1-282

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Myeloid differentiation primary response protein MyD88 protein (1-282AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MYD88

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Andere Bezeichnung: MYD88

Hintergrund:

Background: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

Aliases: Mutant myeloid differentiation primary response 88 antibody, MYD 88 antibody, Myd88 antibody, MYD88_HUMAN antibody, MYD88D antibody, Myeloid differentiation marker 88 antibody, Myeloid differentiation primary response 88 antibody, Myeloid differentiation primary response gene (88) antibody, Myeloid differentiation primary response gene 88 antibody, Myeloid differentiation primary response gene antibody, Myeloid differentiation primary response protein MyD88 antibody, OTTHUMP00000161718 antibody, OTTHUMP00000208595 antibody, OTTHUMP00000209058 antibody, OTTHUMP00000209059 antibody, OTTHUMP00000209060 antibody

UniProt: Q99836

Pathways: NF-kappaB Signalweg, TLR Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades