CISH Antikörper (AA 1-257)

Produktnummer ABIN7149303

Der Kaninchen Polyklonal Anti-CISH-Antikörper wurde für IHC und ELISA validiert. Er ist geeignet, CISH in Proben von Human zu detektieren.

Kurzübersicht für CISH Antikörper (AA 1-257) (ABIN7149303)

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CISH Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-CISH Antikörper

Bindungsspezifität: AA 1-257

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Cytokine-inducible SH2-containing protein (1-257AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CISH

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Andere Bezeichnung: CISH

Hintergrund:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Aliases: BACTS2 antibody, cis 1 antibody, CIS antibody, CIS-1 antibody, CIS1 antibody, Cish antibody, CISH_HUMAN antibody, Cytokine inducible inhibitor of signaling type 1B antibody, Cytokine inducible SH2 containing protein antibody, Cytokine-inducible SH2-containing protein antibody, G18 antibody, Protein G18 antibody, SOCS antibody, Suppressor of cytokine signaling antibody

UniProt: Q9NSE2

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus