Survivin Antikörper (AA 1-130) (Biotin)

Produktnummer ABIN7145208

Der Kaninchen Polyklonal Anti-Survivin-Antikörper wurde für ELISA validiert. Er ist geeignet, Survivin in Proben von Human zu detektieren.

Kurzübersicht für Survivin Antikörper (AA 1-130) (Biotin) (ABIN7145208)

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Survivin Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-Survivin Antikörper (Biotin)

Bindungsspezifität: AA 1-130

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Baculoviral IAP repeat-containing protein 5 protein (1-130AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Survivin

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Andere Bezeichnung: BIRC5

Hintergrund:

Background: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex, directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at \'Thr-3\' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

Aliases: API4 antibody, Apoptosis inhibitor 4 antibody, Apoptosis inhibitor survivin antibody, Apoptosis inhibitor4 antibody, Baculoviral IAP repeat containing 5 antibody, Baculoviral IAP repeat containing protein 5 antibody, Baculoviral IAP repeat-containing protein 5 antibody, BIRC 5 antibody, BIRC5 antibody, BIRC5_HUMAN antibody, EPR 1 antibody, IAP4 antibody, Survivin variant 3 alpha antibody, SVV antibody, TIAP antibody

UniProt: O15392

Pathways: Apoptose, Zellzyklus, Nuclear Hormone Receptor Binding