Serotonin Receptor 2B Antikörper (AA 382-481)

Produktnummer ABIN7142626

Dieses Anti-Serotonin Receptor 2B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Serotonin Receptor 2B in ELISA und IHC. Geeignet für Human.

Kurzübersicht für Serotonin Receptor 2B Antikörper (AA 382-481) (ABIN7142626)

Target: Serotonin Receptor 2B (HTR2B)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Serotonin Receptor 2B Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-Serotonin Receptor 2B Antikörper

Bindungsspezifität: AA 382-481

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human 5-hydroxytryptamine receptor 2B protein (382-481AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Serotonin Receptor 2B

Target: Serotonin Receptor 2B (HTR2B)

Andere Bezeichnung: HTR2B

Hintergrund:

Background: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.

Aliases: 5 HT 2B antibody, 5 HT 2B receptor antibody, 5 HT(2B) antibody, 5 HT2B antibody, 5 hydroxytryptamine (serotonin) receptor 2B antibody, 5 hydroxytryptamine (serotonin) receptor 2B G protein coupled antibody, 5 hydroxytryptamine 2B receptor antibody, 5 hydroxytryptamine receptor 2B antibody, 5-HT-2B antibody, 5-HT2B antibody, 5-hydroxytryptamine receptor 2B antibody, 5HT(2B) antibody, 5HT2B Receptor antibody, 5HT2B_HUMAN antibody, 5HT2F antibody, Htr 2b antibody, Htr2b antibody, NP75 protein antibody, SEROTONIN 5HT2B RECEPTOR antibody, Serotonin receptor 2B antibody, Stomach fundus serotonin receptor antibody

UniProt: P41595

Pathways: JAK-STAT Signalweg, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process