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PDK4 Antikörper (AA 143-333)

Dieses Anti-PDK4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PDK4 in IHC und ELISA. Geeignet für Human.
Produktnummer ABIN7142008

Kurzübersicht für PDK4 Antikörper (AA 143-333) (ABIN7142008)

Target

Alle PDK4 Antikörper anzeigen
PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))

Reaktivität

  • 75
  • 48
  • 8
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 71
  • 13
Kaninchen

Klonalität

  • 75
  • 11
Polyklonal

Konjugat

  • 48
  • 7
  • 4
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PDK4 Antikörper ist unkonjugiert

Applikation

  • 71
  • 40
  • 29
  • 13
  • 13
  • 9
  • 9
  • 8
  • 6
  • 3
  • 2
  • 1
  • 1
  • 1
Immunohistochemistry (IHC), ELISA
  • Bindungsspezifität

    • 15
    • 10
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 143-333

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial protein (143-333AA)

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: IHC:1:20-1:200,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))

    Andere Bezeichnung

    PDK4

    Hintergrund

    Background: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.

    Aliases: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4 antibody, FLJ40832 antibody, mitochondrial antibody, Pdk4 antibody, PDK4_HUMAN antibody, Pyruvate dehydrogenase [lipoamide] kinase isozyme 4 mitochondrial antibody, Pyruvate dehydrogenase kinase 4 antibody, Pyruvate dehydrogenase kinase isoenzyme 4 antibody, Pyruvate dehydrogenase kinase isoform 4 antibody, Pyruvate dehydrogenase kinase isozyme 4 antibody, Pyruvate dehydrogenase kinase isozyme 4 mitochondrial antibody

    UniProt

    Q16654

    Pathways

    PI3K-Akt Signalweg, Hedgehog Signalweg, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effekt
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