MSK1 Antikörper (pSer212)

Produktnummer ABIN7138480

Dieses Anti-MSK1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MSK1 in WB und ELISA. Geeignet für Human.

Kurzübersicht für MSK1 Antikörper (pSer212) (ABIN7138480)

Target: MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MSK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-MSK1 Antikörper

Bindungsspezifität: pSer212

Kreuzreaktivität: Human, Maus

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 212 (A-Y-S(p)-F-C) derived from Human MSK1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MSK1

Target: MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))

Andere Bezeichnung: RPS6KA5

Hintergrund:

Background:

Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).

McCoy CE, et al. (2007) Biochem J 402, 491-501
McCoy CE, et al. (2005)Biochem J 387, 507-17

Aliases: 90 kDa ribosomal protein S6 kinase 5 antibody, EC 2.7.11.1 antibody, KS6A5_HUMAN antibody, MGC1911 antibody, Mitogen and stress activated protein kinase 1 antibody, MSPK1 antibody, Nuclear Mitogen And Stress Activated Protein Kinase 1 antibody, Nuclear mitogen- and stress-activated protein kinase 1 antibody, Ribosomal protein S6 kinase 90kD polypeptide 5 antibody, Ribosomal protein S6 kinase 90 kDa antibody, Ribosomal protein S6 kinase 90 kDa polypeptide 5 antibody, Ribosomal Protein S6 Kinase Alpha 5 antibody, Ribosomal protein S6 kinase alpha-5 antibody, RLPK antibody, RPS6KA5 antibody, RSK Like Protein Kinase antibody, RSK-like protein kinase antibody, RSKL antibody, S6K alpha 5 antibody, S6K-alpha-5 antibody

UniProt: O75582

Pathways: MAPK Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades