EPAS1 Antikörper (AA 547-551)

Produktnummer ABIN7138289

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch EPAS1 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für EPAS1 Antikörper (AA 547-551) (ABIN7138289)

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPAS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-EPAS1 Antikörper

Bindungsspezifität: AA 547-551

Kreuzreaktivität: Human

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: Peptide sequence around aa.547-551(P-E-E-R-L) derived from HumanHIF2A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EPAS1

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Andere Bezeichnung: EPAS1

Hintergrund:

Background:

 Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Aliases: Basic helix loop helix PAS protein MOP2 antibody; Basic-helix-loop-helix-PAS protein MOP2 antibody; bHLHe73 antibody; Class E basic helix-loop-helix protein 73 antibody; ECYT4 antibody; Endothelial PAS domain containing protein 1 antibody; Endothelial pas domain protein 1 antibody; Endothelial PAS domain-containing protein 1 antibody; EPAS 1 antibody; EPAS-1 antibody; EPAS1 antibody; EPAS1_HUMAN antibody; HIF 1 alpha like factor antibody; HIF 2 alpha antibody; HIF-1-alpha-like factor antibody; HIF-2-alpha antibody; HIF2-alpha antibody; HIF2A antibody; HLF antibody; Hypoxia inducible factor 2 alpha antibody; Hypoxia inducible factor 2 alpha subunit antibody; Hypoxia-inducible factor 2-alpha antibody; Member of PAS protein 2 antibody; Member of pas superfamily 2 antibody; MOP 2 antibody; MOP2 antibody; PAS domain-containing protein 2 antibody; PASD2 antibody

UniProt: Q99814

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effekt