IRF9 Antikörper

Produktnummer ABIN7126180

Dieses Anti-IRF9-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von IRF9 in IF und FACS. Geeignet für Human.

Kurzübersicht für IRF9 Antikörper (ABIN7126180)

Target: IRF9 (Interferon Regulatory Factor 9 (IRF9))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IRF9 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-IRF9 Antikörper

Spezifität: Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Kreuzreaktivität (Details): Human

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human IRF9 protein

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: MCF-7, Jurkat or K562 cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu IRF9

Target: IRF9 (Interferon Regulatory Factor 9 (IRF9))

Andere Bezeichnung: IRF9

Hintergrund: IFN alpha responsive transcription factor subunit, Interferon regulatory factor 9, Interferon-stimulated gene factor 3 gamma, interferon-stimulated transcription factor 3, gamma 48 kDa, IRF-9, ISGF-3 gamma, ISGF3 p48 subunit, ISGF3G, p48, Transcriptional regulator ISGF3 subunit gamma,Interferon regulatory factor 9 / IRF-9
Cellular localisation: Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.

Molekulargewicht: 43.34kDa

Gen-ID: 10379, 1706

UniProt: Q00978

Pathways: JAK-STAT Signalweg, Interferon-gamma Pathway, Hepatitis C