IRF9 Antikörper

Produktnummer ABIN7504160

Der Maus Monoklonal anti-IRF9 Antikörper (Klon PCRP-IRF9-2F8) (ABIN7504160) detektiert spezifisch IRF9 in IF und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für IRF9 Antikörper (ABIN7504160)

Target: IRF9 (Interferon Regulatory Factor 9 (IRF9))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IRF9 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: PCRP-IRF9-2F8

Produktdetails anti-IRF9 Antikörper

Verwendungszweck: Interferon regulatory factor 9 / IRF-9 Antibody

Spezifität: Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Kreuzreaktivität (Details): Human

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human IRF9 protein

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

Positive Control: MCF-7, Jurkat or K562 cells.

Known Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu IRF9

Target: IRF9 (Interferon Regulatory Factor 9 (IRF9))

Andere Bezeichnung: IRF9

Hintergrund:

IFN alpha responsive transcription factor subunit, Interferon regulatory factor 9, Interferon-stimulated gene factor 3 gamma, interferon-stimulated transcription factor 3, gamma 48 kDa, IRF-9, ISGF-3 gamma, ISGF3 p48 subunit, ISGF3G, p48, Transcriptional regulator ISGF3 subunit gamma

Jurkat or K562 cells., MCF-7

Molekulargewicht: 43.34kDa

Gen-ID: 10379, 1706

UniProt: Q00978

Pathways: JAK-STAT Signalweg, Interferon-gamma Pathway, Hepatitis C