Retinoblastoma Binding Protein 8 Antikörper

Produktnummer ABIN7118434

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Retinoblastoma Binding Protein 8 in ELISA und WB. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Retinoblastoma Binding Protein 8 Antikörper (ABIN7118434)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Retinoblastoma Binding Protein 8 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-Retinoblastoma Binding Protein 8 Antikörper

Verwendungszweck: RBBP8 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: retinoblastoma binding protein 8

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Andere Bezeichnung: RBBP8

Hintergrund:

Synonyms: DNA endonuclease RBBP8|CtBP-interacting protein (CtIP)|Retinoblastoma-binding protein 8 (RBBP-8)|Retinoblastoma-interacting protein and myosin-like (RIM)|Sporulation in the absence of SPO11 protein 2 homolog (SAE2)|RBBP8|CTIP

Background: Endonuclease that cooperates with the MRE11-RAD50-NBN(MRN) complex in processing meiotic and mitotic double-strand breaks(DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining(A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.

Molekulargewicht: 120 kDa

Gen-ID: 5932

UniProt: Q99708

Pathways: Zellzyklus, DNA Reparatur