NEIL1 Antikörper

Produktnummer ABIN7113799

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch NEIL1 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für NEIL1 Antikörper (ABIN7113799)

Target: NEIL1 (Endonuclease VIII-Like 1 (NEIL1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NEIL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-NEIL1 Antikörper

Verwendungszweck: NEIL1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: nei endonuclease VIII-like 1(E. coli)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu NEIL1

Target: NEIL1 (Endonuclease VIII-Like 1 (NEIL1))

Andere Bezeichnung: NEIL1

Hintergrund:

Synonyms: Endonuclease 8-like 1|DNA glycosylase/AP lyase Neil1|DNA-(apurinic or apyrimidinic site) lyase Neil1|Endonuclease VIII-like 1|FPG1|Nei homolog 1 (NEH1)|Nei-like protein 1|NEIL1

Background: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine(Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP(apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'-and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine(5hmC), suggesting that it acts as a specific reader of 5hmC.

Molekulargewicht: 44 kDa

Gen-ID: 79661

UniProt: Q96FI4

Pathways: DNA Reparatur