NEIL1 Antikörper (Internal Region)
-
- Target Alle NEIL1 Antikörper anzeigen
- NEIL1 (Endonuclease VIII-Like 1 (NEIL1))
-
Bindungsspezifität
- Internal Region
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser NEIL1 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- NEIL1 Antibody detects endogenous levels of total NEIL1.
- Homologie
- Horse,Sheep
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human NEIL1, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product NEIL1 Primärantikörper
-
-
- Applikationshinweise
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
-
- Target
- NEIL1 (Endonuclease VIII-Like 1 (NEIL1))
- Andere Bezeichnung
- NEIL1 (NEIL1 Produkte)
- Synonyme
- FPG1 antikoerper, NEI1 antikoerper, hFPG1 antikoerper, 2810450N13Rik antikoerper, Nei1 antikoerper, nei-like DNA glycosylase 1 antikoerper, nei like DNA glycosylase 1 antikoerper, nei endonuclease VIII-like 1 (E. coli) antikoerper, Neil1 antikoerper, NEIL1 antikoerper
- Hintergrund
-
Description: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Gene: NEIL1
- Molekulargewicht
- 44 kDa
- Gen-ID
- 79661
- UniProt
- Q96FI4
- Pathways
- DNA Reparatur
-