Cyclin D1 Antikörper (AA 65-245)

Produktnummer ABIN7113141

Dieses Anti-Cyclin D1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Cyclin D1 in WB und ELISA. Geeignet für Human und Maus.

Kurzübersicht für Cyclin D1 Antikörper (AA 65-245) (ABIN7113141)

Target: Cyclin D1 (CCND1)

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cyclin D1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 8E8

Produktdetails anti-Cyclin D1 Antikörper

Bindungsspezifität: AA 65-245

Verwendungszweck: CCND1 antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 65-245aa

Immunogen: cyclin D1

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB: 1:2000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu Cyclin D1

Target: Cyclin D1 (CCND1)

Andere Bezeichnung: CCND1

Hintergrund:

Synonyms: G1/S-specific cyclin-D1|B-cell lymphoma 1 protein (BCL-1)|BCL-1 oncogene|PRAD1 oncogene|CCND1|BCL1|PRAD1

Background: CCND1(cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma(MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.

Molekulargewicht: 36 kDa

Gen-ID: 595

UniProt: P24385

Pathways: PI3K-Akt Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, ER-Nucleus Signaling