CARD9 Antikörper

Produktnummer ABIN7112379

Dieses Anti-CARD9-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CARD9 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für CARD9 Antikörper (ABIN7112379)

Target: CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CARD9 Antikörper

Verwendungszweck: CARD9 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: caspase recruitment domain family, member 9

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu CARD9

Target: CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))

Andere Bezeichnung: CARD9

Hintergrund:

Synonyms: Caspase recruitment domain-containing protein 9 (hCARD9)|CARD9

Background: Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors(TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases(MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B(By similarity). Controls CLEC7A(dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A(dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper(TH-17) cells.

Molekulargewicht: 50-59 kDa

Gen-ID: 64170

UniProt: Q9H257

Pathways: Activation of Innate immune Response