Caspase 3 Antikörper
Kurzübersicht für Caspase 3 Antikörper (ABIN7112361)
Target
Alle Caspase 3 (CASP3) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Aufreinigung
- protein A+G purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- caspase 3, apoptosis-related cysteine peptidase
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Isotyp
- IgG1
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Applikationshinweise
- WB: 1:500-1:2000, IHC: 1:50-1:300, IF: 1:50-1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- 0.01MPBS pH 7.4,
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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Haltbarkeit
- 12 months
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- Caspase 3 (CASP3)
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Andere Bezeichnung
- CASP3
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Hintergrund
- Synonyms:Apopain, CASP 3, CASP3, Caspase 3, Caspase 3/p17, Caspase3, CPP 32, CPP32, CPP32B, Cysteine protease CPP32, Protein Yama, SCA 1, SREBP cleavage activity 1 Background:Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase(PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.
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Molekulargewicht
- 32-35 kDa, 19 kDa, 17 kDa
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Gen-ID
- 836
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UniProt
- P42574
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Pathways
- Apoptose, Caspase Kaskade in der Apoptose, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
Target
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