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Caspase 3 Antikörper (pSer150)

Name: Caspase 3 Antikörper (pSer150)
SKU: ABIN6254994
Price: 698.46 EUR
Availability: InStock

CASP3 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

Western blot analysis of extracts from rat spleen, mouse spleen, using Phospho-Caspase 3 (Ser150) Antibody.

Western blot analysis of Caspase 3 phosphorylation expression in Etoposide treated Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

Western blot analysis of extracts of various tissue sample,using Phospho-Caspase 3 (Ser150) Antibody .

IF/ICC

ABIN6267520 at 1/50 staining human colon cancer tissue sections by IHC-P.

IHC

6 Abbildungen

(1 reference)

Produktnummer ABIN6254994

Datenblatt (PDF)

Target Alle Caspase 3 (CASP3) Antikörper anzeigen

Caspase 3 (CASP3)
Bindungsspezifität
19

16

16

16

16

16

16

15

14

13

11

11

10

9

8

7

7

6

6

6

5

5

4

4

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer150
Reaktivität
281

195

148

31

17

10

10

9

7

7

5

5

4

3

3

2

1

1

1
Human, Maus, Ratte
Wirt
281

42

4

2

2
Kaninchen
Passende Sekundärantikörper
Klonalität
273

57
Polyklonal
Konjugat
161

27

21

14

11

11

9

9

9

9

9

6

6

6

6

6

6

2

2

1
Dieser Caspase 3 Antikörper ist unkonjugiert
Applikation
254

108

104

85

79

65

52

36

34

29

27

20

10

6

3

2

2

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität

Phospho-Caspase 3 (Ser150) Antibody detects endogenous levels of Caspase 3 only when phosphorylated at Serine 150.

Homologie

Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen

A synthesized peptide derived from human Caspase 3 around the phosphorylation site of Ser150.

Isotyp

IgG

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anti-Caspase 3 (CASP3) (AA 100-200) antibody
CASP3 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 29-175) antibody
CASP3 Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C

Informationen zur Lagerung

Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit

12 months
Cui, Lin, Shi, Pan: "Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf-ERK pathway." in: Biochemical and biophysical research communications, Vol. 491, Issue 2, pp. 277-284, (2017) (PubMed).
Target

Caspase 3 (CASP3)

Andere Bezeichnung

CASP3 (CASP3 Produkte)

Synonyme

CPP32 antikoerper, CPP32B antikoerper, SCA-1 antikoerper, A830040C14Rik antikoerper, AC-3 antikoerper, Apopain antikoerper, CC3 antikoerper, Caspase-3 antikoerper, Lice antikoerper, Yama antikoerper, mldy antikoerper, xcpp32 antikoerper, casp3 antikoerper, zgc:100890 antikoerper, CASP-3 antikoerper, caspase-3 antikoerper, caspase 3 antikoerper, caspase 3 S homeolog antikoerper, caspase 3, apoptosis-related cysteine peptidase a antikoerper, caspase 3, apoptosis-related cysteine peptidase antikoerper, CASP3 antikoerper, Casp3 antikoerper, casp3.S antikoerper, casp3a antikoerper

Hintergrund

Description: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Gene: CASP3

Molekulargewicht

34kDa

Gen-ID

836

UniProt

P42574

Pathways

Apoptose, Caspase Kaskade in der Apoptose, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation