BAX Antikörper

Produktnummer ABIN7111962

Dieses Anti-BAX-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BAX in WB, IHC, ELISA, FACS und IP. Geeignet für Human, Maus, Ratte, Kaninchen und Schaf.

Kurzübersicht für BAX Antikörper (ABIN7111962)

Target: BAX (BCL2-Associated X Protein (BAX))

Reaktivität: Human, Maus, Ratte, Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP)

Produktdetails anti-BAX Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: BCL2-associated X protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:10000, IP: 1:1000-1:10000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu BAX

Target: BAX (BCL2-Associated X Protein (BAX))

Andere Bezeichnung: BAX

Hintergrund: Synonyms:BCL2L4,Apoptosis regulator BAX, BAX Background:BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction(PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria(PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis(PMID: 8183579).

Molekulargewicht: 21 kDa

Gen-ID: 581

UniProt: Q07812

Pathways: p53 Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response