IL-6 Receptor Antikörper (AA 20-365)

Produktnummer ABIN7092952

Der Kaninchen Monoklonal Anti-IL-6 Receptor-Antikörper wurde für ELISA und FACS validiert. Er ist geeignet, IL-6 Receptor in Proben von Human zu detektieren.

Kurzübersicht für IL-6 Receptor Antikörper (AA 20-365) (ABIN7092952)

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser IL-6 Receptor Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Klon: DM152

Produktdetails anti-IL-6 Receptor Antikörper

Bindungsspezifität: AA 20-365

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Immunogen: Recombinant human IL6R(Leu20-Pro365) (ABIN6964085) produced by using human HEK293 cells

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1/5000-10000,Flow Cyt 1/100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.,0.1 % Procline 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Details zu IL-6 Receptor

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Andere Bezeichnung: IL6R

Hintergrund: Synonyms:CD126, gp80, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ
Description:This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Molekulargewicht: 51.5KDa

Pathways: JAK-STAT Signalweg, Autophagie, Growth Factor Binding, Cancer Immune Checkpoints